当前位置:  首页 >> 最新重要论文

最新重要论文

The role of B cell antigen presentation in the initiation of CD4+ T cell response, Immunol Rev, 18 Apr 2020

发布时间:2020年04月18日

Immunological Reviews, 18 April, 2020, DOI:满堂彩网香港二分彩

The role of B cell antigen presentation in the initiation of CD4+ T cell response

Zhaolin Hua and Baidong Hou

Abstract

B cells have been known for their ability to present antigens to T cells for almost 40 years. However, the precise roles of B cell antigen presentation in various immune responses are not completely understood. The term “professional” antigen‐presenting cells (APCs) was proposed to distinguish APCs that are required for initiating the immune responses from those use antigen presentation to enhance their own effector functions. Unlike dendritic cells, which are defined as professional APCs for their well‐established functions in activating naive T cells, B cells have been shown in the past to mostly present antigens to activated CD4+ T cells mainly to seek help from T helper cells. However, recent evidence suggested that B cells can act as professional APCs under infectious conditions or conditions mimicking viral infections. B cell antigen receptors (BCRs) and the innate receptor Toll‐like receptors are activated synergistically in response to pathogens or virus‐like particles, under which conditions B cells are not only potent but also the predominant APCs to turn naive CD4+ T cells into T follicular helper cells. The discovery of B cells as professional APCs to initiate CD4+ T cell response provides a new insight for both autoimmune diseases and vaccine development.

文章链接:https://onlinelibrary.wiley.com/doi/full/10.1111/imr.12859

 

 

    附件下载:
网站地图 金福彩票网上海快3 金福彩票网上海快3 驴彩彩票福彩3D
申博sunbet彩赢网 申博太阳神娱乐网 申博网上娱乐充值 申博sunbet彩赢网
银河彩票客户端下载 冠军彩票广西快三 long8 澳门金沙注册送20登入
金福彩票网上海快3 满堂彩网香港五分彩 金福彩票网低频游戏 满堂彩网广西快3
满堂彩网福彩3D 满堂彩网上海时时乐 满堂彩网手机下注 满堂彩网时时彩
XSB591.COM 1112126.COM S6187.COM 215SUN.COM S618E.COM
DC537.COM XSB5555.COM 8WHS.COM XSB818.COM 9927w.com
XSB593.COM DC362.COM 538PT.COM XSB198.COM 99sbsun.com
18888shenbo.com 676sj.com 255PT.COM 191sj.com 222xsb.com